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KMID : 0882420080740000179
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Korean Journal of Medicine
2008 Volume.74 No. 0 p.179 ~ p.183
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A case of false-positive multidrug-resistant tuberculosis confirmed by restriction fragment length polymorphism analysis
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Hong Seok-Chan
Kim Mi-Na
PArk Young-Kil
Jo Kyung-Wook
Chong Yong-Pill
Kim Won-Dong
Shim Tae-Sun
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Abstract
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Microbiological confirmation is the gold standard method for the diagnosis of tuberculosis (TB), but there are numerous reports of false-positive cultures for Mycobacterium tuberculosis. Although the prevalence of TB in Korea is still high, the occurrence of false-positive cultures for M. tuberculosis has rarely been recognized or reported. We report a false-positive culture of multidrug-resistant M. tuberculosis due to cross-contamination, as confirmed by restriction fragment length polymorphism (RFLP) analysis. Clinicians should always suspect the possibility of a false-positive culture result for M. tuberculosis when there is a discrepancy between the clinical and bacteriological results, with low colony counts on sputum culture for M. tuberculosis. (Korean J Med 74:S179-S183, 2008)
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KEYWORD
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Mycobacterium tuberculosis, False-positive culture, Crossover contamination, RFLP analysis
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